North America Oligonucleotide Synthesis Market Regional Analysis, Key Players, Future Projection 2027

The North America Oligonucleotide Synthesis Market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.

North America Oligonucleotide Synthesis Market – Strategic Overview

The growth of the North America Oligonucleotide Synthesis Market is being propelled by several key factors, including increased investments in pharmaceutical and biotechnology sectors, substantial funding from government organizations, and a growing number of market players focusing on oligonucleotide synthesis. These developments are expected to significantly boost market expansion throughout the forecast period.

Oligonucleotides, short single-stranded sequences of DNA, play a crucial role in numerous biological applications. They are used as sequence-specific binding agents, allowing researchers to detect the presence of specific DNA sequences. Their applications span a broad range of fields, including disease diagnosis, biotechnology research, therapeutics, forensics, and drug discovery. One notable example is their use in diagnosing genetic disorders such as sickle cell anemia, which involves a single base-pair mutation in the β-globin gene. Labeled oligonucleotide probes enable precise detection of such mutations under stringent hybridization conditions.

In addition to diagnostic applications, oligonucleotides are increasingly used in greener, more efficient chemical synthesis processes. By assembling oligonucleotides into longer DNA fragments that encode synthetic genes, researchers can program bacteria or yeast cells to produce desired enzymes, which has far-reaching implications for industrial biotechnology.

Therapeutically, oligonucleotides are valuable tools for targeting and modulating malfunctioning genes. For example, Ionis Pharmaceuticals has been at the forefront of developing antisense oligonucleotide (ASO) therapies. These therapies can silence or correct the expression of faulty genes, offering significant potential in treating genetic diseases.

NORTH AMERICA OLIGONUCLEOTIDE SYNTHESIS MARKET SEGMENTATION

North America Oligonucleotide Synthesis Market By Product

• Synthesized Oligonucleotides
• Primers
• Probes
• Large-Scale Synthesis
• Others
• Reagents
• Equipment

North America Oligonucleotide Synthesis Market By Application

• Research
• Diagnostics
• Therapeutics

North America Oligonucleotide Synthesis Market By End User

• Academic Research Institutes
• Pharmaceutical & Biotechnology Companies
• Diagnostic Laboratories
• Other End Users

North America Oligonucleotide Synthesis Market By Geography

• North America
• US
• Canada
• Mexico

North America Oligonucleotide Synthesis Market Company Profiles

• Thermo Fisher Scientific Inc.
• GenScript
• Molecular Assemblies
• Twist Biosciences
• Evonetix
• DNA Script
• Nuclera Nucleics
• Camena Bioscience
• Synthomics
• Ansa Biotechnologies

Canada has also been contributing to North America Oligonucleotide Synthesis Market development through active clinical research. In January 2019, a Phase 3 clinical trial was initiated across Canada and the United States to evaluate the efficacy of RG6042 (formerly IONIS-HTTRx), an antisense oligonucleotide treatment for Huntington’s disease. Originally developed by Ionis Pharmaceuticals and later acquired by Roche, RG6042 is designed to target and eliminate mutant huntingtin proteins—the primary cause of the disease. The trial was expected to span six locations across five Canadian provinces, underscoring Canada’s involvement in advancing oligonucleotide-based therapies.

Within North America, the United States is anticipated to dominate the regional market. This is largely due to the increasing inflow of investments and financial support directed toward manufacturing companies, academic institutions, and research organizations. These resources are fostering the development of gene synthesis-based solutions such as precision medicine and innovative therapeutics, positioning the U.S. as a key contributor to regional North America Oligonucleotide Synthesis Market growth.

Strategic Insights for North America Oligonucleotide Synthesis Market Stakeholders

Strategic insights into the North America Oligonucleotide Synthesis Market offer a data-driven perspective of the industry landscape—highlighting current trends, major players, and regional dynamics. These insights help stakeholders identify untapped market segments, create unique value propositions, and differentiate themselves from competitors. By leveraging analytics and maintaining a forward-looking outlook, investors, manufacturers, and other participants can anticipate market shifts and adapt accordingly. Ultimately, these insights support informed decision-making, enabling long-term profitability and sustainable growth in this dynamic and rapidly evolving sector.

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights